Physico-chemical properties of the mannosylated SLNas satisfied the requirements relative to suitable respirability, drug payload, and AM active targeting. SLNas were functionalized with a synthesized mannosylated surfactant, both alone and in a blend with sodium taurocholate, to achieve an active targeting to mannose receptors present on alveolar macrophages (AM). Based on this concept, the present research focused on the interactions between pulmonary surfactant and Solid Lipid Nanoparticle assemblies (SLNas), loaded with rifampicin, an anti-tuberculosis drug. As a matter of fact, the formation of a lipid corona layer around the nanoparticles could modulate the cell internalization and the fate of the transported drugs. For inhaled nanoparticles, which are designed for being deposited on alveolar epithelium and taken up by macrophages, it is relevant to investigate the interactions with pulmonary surfactant lining alveoli. mimicking of physiological conditions is crucial for the success of accurate in vitro studies. 11 Department of Life Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy. 10 Department of Life Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy. 9 Department of Life Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy. 8 Department of Engineering "Enzo Ferrari", University of Modena and Reggio Emilia, 41125 Modena, Italy. 7 Food and Drug Department, University of Parma, 43124 Parma, Italy. 6 Department of Engineering "Enzo Ferrari", University of Modena and Reggio Emilia, 41125 Modena, Italy. 5 Department of Engineering "Enzo Ferrari", University of Modena and Reggio Emilia, 41125 Modena, Italy. 4 Department of Life Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy. 3 Department of Engineering "Enzo Ferrari", University of Modena and Reggio Emilia, 41125 Modena, Italy. 2 Department of Life Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.
0 Comments
Leave a Reply. |